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Quality products?make an important contribution to long-term revenue and profitability. Quality Manufacturer Supply High Purity 99% Tariquidar 206873-63-4 with Reasonable Price
1.What is the Tariquidar ?
Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer.
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![2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide](/upload/2026/11/00f7f853223047c5b9da1132d54886b8_a302332e-e84b-49f1-87fd-460557c4aafb.png)
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849668-91-3
2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide
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84741-86-6
quinoline-3-carbonyl chloride
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206873-63-4
tariquidar
| Conditions | Yield |
|---|---|
|
In
dichloromethane;
at 20 ℃;
for 24h;
|
75%
|
|
With
ammonia; triethylamine;
In
tetrahydrofuran; ethanol;
at 50 ℃;
|
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4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid
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206873-63-4
tariquidar
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
4
steps
1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 83 °C
2: sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C
3: palladium 10% on activated carbon; ammonium formate; hydrogen / methanol / 4 h / Reflux
4: dichloromethane / 24 h / 20 °C
With
thionyl chloride; palladium 10% on activated carbon; hydrogen; ammonium formate; sodium hydrogencarbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
|
2.What is the CAS number for Tariquidar ?
The CAS number of Tariquidar is 206873-63-4.
More information of Tariquidar 206873-63-4 are:
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CAS?Number |
206873-63-4 |
|
Density |
1.276g/cm3 |
|
Boiling Point |
716°Cat760mmHg |
|
Flash Point |
386.8°C |
|
Vapor Pressure |
2.37E-20mmHg at 25°C |
|
Refractive Index |
1.662 |
|
HS CODE |
2933499090 |
|
PSA |
111.25000 |
|
LogP |
6.45850 |
|
Pka |
10.67±0.70(Predicted) |
3.What are another words for Tariquidar ?
Synonyms?for?Tariquidar 206873-63-4:Tariquidar;XR 9576
4.What is the molecular formula of Tariquidar?
The chemical formula of ?Tariquidar is?C38 H38 N4 O6 which containing 38 Carbon atoms,38 Hydrogen atoms,4 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight of??Tariquidar?is 646.743.
5.What is Tariquidar (206873-63-4) used for?
Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine and paclitaxel in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug sensitive cell levels (EC50 = 487 nM). Tariquidar also enhances the distribution of its substrates, increasing the amount of substrate entering the CNS. When administered at doses of 2 and 6.25 mg/kg in mice in combination with the peripherally-restricted opioid loperamide, the latency to paw withdrawal in a hot plate assay increases, indicating that loperamide is transported into the CNS.
InChI:InChI=1/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)
Relevant articles related to Tariquidar:
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Article |
Source |
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Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives |
Li, Xu-Qin,Wang, Lin,Lei, Yan,Hu, Tao,Zhang, Fei-Long,Cho, Chi-Hin,To, Kenneth K.W. , p. 560 - 572 (2015/07/28) |
6.Buy Tariquidar with the best price .
Jiangxi Lixin Pharmaceutical Co.,Ltd. is a quality supplier of Tariquidar. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Tariquidar 206873-63-4.
