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Top Quality Chinese Manufacturer supply 616201-80-0 LorcaserinA
- Molecular Formula: C11H14Cl N
- Molecular Weight: 195.692
- Boiling Point: 288ºC
- PKA: 9.99±0.40(Predicted)
- Flash Point: 128 ºC
- PSA： 12.03000
- Density: 1.075g/cm3
- LogP: 2.91800
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616201-80-0 Process route
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![1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride](/upload/2026/8/da260ef7cab94683950150063b585af2_47985883-c62e-47f4-9004-dc2db0db437a.png)
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953789-37-2
1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride
-
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616201-80-0,616202-92-7
(+/-)-Lorcaserin
| Conditions | Yield |
|---|---|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 120 - 125 ℃;
Inert atmosphere;
|
99%
|
|
With
aluminum (III) chloride;
at 120 - 125 ℃;
for 3h;
Inert atmosphere;
Large scale;
|
97%
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 135 - 140 ℃;
|
96.1%
|
|
With
aluminum oxide;
In
1,2-dichloro-benzene;
at 130 - 140 ℃;
Inert atmosphere;
|
96.1%
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 140 ℃;
for 10h;
|
95%
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 125 - 130 ℃;
for 3h;
|
90%
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 130 ℃;
for 16h;
Solvent;
|
78.2%
|
|
1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride;
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 125 - 130 ℃;
for 14 - 18h;
With
water;
In
1,2-dichloro-benzene;
at 60 ℃;
With
sodium hydroxide;
In
cyclohexane; water;
at 20 ℃;
for 1h;
pH=>= 13;
|
|
|
1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride;
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 125 - 130 ℃;
for 14 - 18h;
With
sodium hydroxide;
In
cyclohexane; water;
pH=> 13;
|
|
|
1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride;
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 125 - 130 ℃;
for 14 - 18h;
Industry scale;
With
sodium hydroxide;
In
cyclohexane; water;
at 20 ℃;
for 0.5h;
Industry scale;
|
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 126 ℃;
for 16h;
Temperature;
Inert atmosphere;
Large scale;
|
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 120 ℃;
|
|
|
With
aluminum (III) chloride;
In
1,2-dichloro-benzene;
at 150 ℃;
for 1h;
Temperature;
Reagent/catalyst;
|
-
-
N-allyl-N-(4-chlorophenethyl)carbamic acid tert-butyl ester
-
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616201-80-0,616202-92-7
(+/-)-Lorcaserin
| Conditions | Yield |
|---|---|
|
With
aluminum (III) chloride;
In
chlorobenzene;
at 110 ℃;
Solvent;
Temperature;
|
81.6%
|
|
Multi-step reaction
with
2
steps
1: hydrogenchloride / ethyl acetate / 20 °C / pH 2 / Large scale
2: aluminum (III) chloride / 1,2-dichloro-benzene / 4 h / 110 °C / Inert atmosphere; Large scale
With
hydrogenchloride; aluminum (III) chloride;
In
ethyl acetate; 1,2-dichloro-benzene;
2: |Friedel-Crafts Alkylation;
|
|
|
Multi-step reaction
with
2
steps
1: hydrogenchloride / ethyl acetate / 20 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
With
hydrogenchloride; aluminum (III) chloride;
In
ethyl acetate; 1,2-dichloro-benzene;
2: |Friedel-Crafts Alkylation;
|
|
|
Multi-step reaction
with
2
steps
1: dichloromethane / 25 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
With
aluminum (III) chloride;
In
dichloromethane; 1,2-dichloro-benzene;
2: |Friedel-Crafts Alkylation;
|
|
|
Multi-step reaction
with
2
steps
1: hydrogenchloride / water; ethyl acetate / 20 °C
2: aluminum (III) chloride / 1,2-dichloro-benzene / 110 °C
With
hydrogenchloride; aluminum (III) chloride;
In
water; ethyl acetate; 1,2-dichloro-benzene;
|
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