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Manufacturer supply 4-(3-Pyridyl)-2-chloropyrimidine 483324-01-2 with sufficient stock and high standard
- Molecular Formula: C9H6ClN3
- Molecular Weight: 191.62
- Vapor Pressure: 3.14E-06mmHg at 25°C
- Refractive Index: 1.599
- Boiling Point: 399.5 °C at 760 mmHg
- PKA: 2.34±0.12(Predicted)
- Flash Point: 227.7 °C
- PSA: 38.67000
- Density: 1.309 g/cm3
- LogP: 2.19200
4-(3-Pyridyl)-2-chloropyrimidine(Cas 483324-01-2) Usage
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General Description |
4-(3-Pyridyl)-2-chloropyrimidine, also known as 2-Chloro-4-(3-pyridyl)pyrimidine, is a chemical compound with the molecular formula C8H6ClN3. It is a pyrimidine derivative that contains a chloro group and a pyridyl group as its functional groups. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also employed in the development of biologically active compounds, including potential anticancer and antimicrobial agents. Additionally, 4-(3-Pyridyl)-2-chloropyrimidine may be utilized in various research applications in the fields of medicinal and organic chemistry. |
InChI:InChI=1/C9H6ClN3/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H
483324-01-2 Relevant articles
SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE
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Page/Page column 35, (2021/04/23)
Processes and useful intermediates for t...
Investigations into the potential role of metabolites on the anti-leukemic activity of imatinib, nilotinib and midostaurin
Manley, Paul W.
, p. 561 - 570 (2019/09/03)
The efficacy and side-effects of drugs d...
As Hedgehog signal transduction pyrimidine amines and pyridine amine inhibitors
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Paragraph 0437-0441; 0967-0971, (2019/06/26)
The invention relates to pyrimidinamine ...
N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity, and preparation method thereof
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, (2019/02/19)
The invention discloses an N-(5-amino-2-...
483324-01-2 Process route
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3934-20-1
2,6-Dichloropyrimidine
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1692-25-7
3-pyridylboronic acid
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-
483324-01-2
2-chloro-4-(pyridin-3-yl)pyrimidine
| Conditions | Yield |
|---|---|
|
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate;
In
tetrahydrofuran; water;
at 85 ℃;
for 12h;
Inert atmosphere;
|
81%
|
|
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
1,4-dioxane; water;
at 90 ℃;
for 4h;
Reagent/catalyst;
Temperature;
Inert atmosphere;
Green chemistry;
|
74.6%
|
|
With
sodium carbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; water;
for 16h;
Heating;
Reflux;
Inert atmosphere;
|
73%
|
|
With
bis-triphenylphosphine-palladium(II) chloride;
In
1,4-dioxane;
for 14h;
Reflux;
Inert atmosphere;
|
52%
|
|
With
sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; water;
at 60 ℃;
for 16h;
|
|
|
With
[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate;
In
1,2-dimethoxyethane; water;
at 100 ℃;
for 1h;
|
|
|
With
bis-triphenylphosphine-palladium(II) chloride; triethylamine;
at 80 ℃;
|
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626-55-1,163928-56-1
3-Bromopyridine
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1722-12-9,1195939-87-7
2-chloropyrimidine
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483324-01-2
2-chloro-4-(pyridin-3-yl)pyrimidine
| Conditions | Yield |
|---|---|
|
3-Bromopyridine; 2-chloropyrimidine;
With
n-butyllithium;
In
diethyl ether; hexane;
at -30 - 0 ℃;
for 1.5h;
With
water; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; hexane;
at 23 ℃;
for 0.25h;
|
94%
|
|
3-Bromopyridine;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
2-chloropyrimidine;
In
diethyl ether; hexane;
at -30 - 0 ℃;
for 1.66667h;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; hexane; water;
at 0 - 20 ℃;
for 0.25h;
|
53%
|
483324-01-2 Upstream products
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626-55-1
3-Bromopyridine
-
3934-20-1
2,6-Dichloropyrimidine
-
1722-12-9
2-chloropyrimidine
-
1692-25-7
3-pyridylboronic acid
483324-01-2 Downstream products
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112675-67-9
N-(4-methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
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181065-58-7
N-(4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
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611225-84-4
2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine
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1114991-73-9
4-{[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl}benzenesulfonamide