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1.What is the SENECIONINE ?
ChEBI: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties. It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine. Senecionine (20 μM) induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes and increases apoptosis in a concentration-dependent manner. In rats, senecionine (35 mg/kg, p.o.) induces liver injury, increases serum levels of bilirubin and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum. Senecionine-induced hepatotoxicity is associated with lipid peroxidation and glutathione depletion.
2.What is the CAS number for SENECIONINE ?
The CAS number of SENECIONINE is 130-01-8.
3.What are another words for SENECIONINE ?
Synonyms?for?SENECIONINE 130-01-8:Senecionan-11,16-dione,12-hydroxy-; Senecionine (6CI,7CI,8CI); (-)-Senecionine; Aureine; NSC 89935;Senecionin; [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-,[5R-(3Z,5R*,6R*,14aR*,14bR*)]-
4.What is SENECIONINE (130-01-8) used for?
InChI:InChI=1/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-/m1/s1
Relevant articles related to SENECIONINE:
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Total synthesis of optically active integerrimine, a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type. III. Regioselective elaboration of the unsymmetrical twelve-membered dilactone and total synthesis of (-)-integerrimine |
Niwa,Miyachi,Uosaki,et al. , p. 4609 - 4610 (1986) |
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Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris |
Tu,Konno,Soejarto,Waller,Bingel,Molyneux,Edgar,Cordell,Fong , p. 461 - 463 (1988) |
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A synthesis of senecionine, a representative of hepatoxic, macrocyclic pyrrolizidine alkaloids of retronecine type |
Niwa,Sakata,Yamada , p. 1990 - 1993 (1994) |
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